- A new oxorhenium(V) complex with benzothiazole derived ligand: Relative stability and global chemical reactivity indices
-
A new rhenium complex, cis-[ReO(btmp)PPh3Cl2] (2a) with 2-benzothiazolyl-5-methoxyphenol (Hbtmp) has been synthesized and characterized by means of FT-IR, UV-Vis, 1H NMR and elemental analyses. The structural parameters of
- Bhattacharya, Arnab,Naskar, Jnan Prakash,Saha, Pinki,Ganguly, Rakesh,Saha, Baptu,Choudhury, Swagata Tarat,Chowdhury, Shubhamoy
-
-
Read Online
- Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
-
A high throughput screen (HTS) identified a novel, but weak (EC50 = 6.2 μM, 97% Glu Max) mGlu4 PAM chemotype based on a 1,4-thiazepane core, VU0544412. Reaction development and chemical optimization delivered a potent mGlu4 PAM VU6022296 (EC50 = 32.8 nM, 108% Glu Max) with good CNS penetration (Kp = 0.45, Kp,uu = 0.70) and enantiopreference. Finally, VU6022296 displayed robust, dose-dependent efficacy in reversing Haloperidol-Induced Catalepsy (HIC), a rodent preclinical Parkinson's disease model.
- Kent, Caitlin N.,Fulton, Mark G.,Stillwell, Kaylee J.,Dickerson, Jonathan W.,Loch, Matthew T.,Rodriguez, Alice L.,Blobaum, Anna L.,Boutaud, Olivier,Rook, Jerri L.,Niswender, Colleen M.,Conn, P. Jeffrey,Lindsley, Craig W.
-
-
Read Online
- Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives
-
Abstract: Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeo
- Gadekar, Sachin P.,Lande, Machhindra K.
-
p. 1253 - 1267
(2021/01/06)
-
- Direct Oxygenation of C-H Bonds through Photoredox and Palladium Catalysis
-
This report presents the oxygenation of C-H bonds via the merger of photocatalysis and Pd catalysis. Herein, we describe the utilization of a photocatalyst to oxidize an organopalladium(II) intermediate to high-valent PdIII or PdIV intermediates, which promotes the formation of C-O bonds. The demonstrated method works efficiently with various directing groups, such as oxime ether and benzothiazole. The applicability of this direct C-O bond formation method is shown by synthesizing several metal complexes of 2-(benzo[d]thiazol-2-yl)phenol that can be used in organic light-emitting diodes and pharmaceuticals.
- Paul, Amrita,Shah, Sk. Sheriff,Shee, Maniklal,Singh, Amit Kumar,Singh, N. D. Pradeep
-
p. 3426 - 3439
(2020/03/23)
-
- Metal-organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway
-
Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH2-MIL-125(Ti) MOF surface through electron deficient Ti4+ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.
- Sankar, Velayudham,Karthik, Peramaiah,Neppolian, Bernaurdshaw,Sivakumar, Bitragunta
-
p. 1021 - 1027
(2020/01/31)
-
- A turn-on fluorescent sensor for selective detection of hydrazine and its application in Arabidopsis thaliana
-
In this work, a primary method was constructed for detecting hydrazine in plant, thus accomplished the closed-loop monitoring of hydrazine circulation within manufacture, environment, plants, animals and human. From a series of sensors, QYL-1 was selected
- Qi, Ya-Lin,Chen, Jian,Zhang, Bo,Li, Hua,Li, Dong-Dong,Wang, Bao-Zhong,Yang, Yu-Shun,Zhu, Hai-Liang
-
-
- Metallaphotoredox-Mediated Csp2-H Hydroxylation of Arenes under Aerobic Conditions
-
The direct hydroxylation of 2-arylpyridines and 2-arylbenzothiazoles via the merger of organic photoredox and metal catalysis is reported where 4CzIPN is used as the visible-light photocatalyst and Pd(OAc)2 as the metal catalyst. This method has been employed to synthesize organic molecules exhibiting excited-state intramolecular proton transfer properties for generating tunable luminescence responses.
- Shah, Sk. Sheriff,Paul, Amrita,Bera, Manoranjan,Venkatesh, Yarra,Singh, N. D. Pradeep
-
p. 5533 - 5536
(2018/09/21)
-
- Highly efficient AgNO3-catalyzed approach to 2-(benzo[d]azol-2-yl)phenols from salicylaldehydes with 2-aminothiophenol, 2-aminophenol and benzene-1,2-diamine
-
A new, convenient and efficient AgNO3-catalyzed strategy for the preparation of 2-(benzo[d]azol-2-yl)phenol derivatives in good to excellent yields (63–98%) is described. The reaction proceeds via condensation/intramolecular nucleophilic addition/oxidation process between substituted salicylaldehydes and 2-aminothiophenol, 2-aminophenol or benzene-1,2-diamine under mild reaction conditions. Notably, this reaction utilizes cheap AgNO3 as a readily available and low-cost benign oxidant at low catalyst loadings with excellent functional group tolerance.
- He, Xinwei,Wu, Yuhao,Jin, Wenjing,Wang, Xiaoshun,Wu, Cong,Shang, Yongjia
-
-
- Unified synthesis of mono/bis-arylated phenols via RhIII-catalyzed dehydrogenative coupling
-
2,6-Bis-arylated phenols are rarely reported and are synthetically challenging. Directed C-H functionalization reactions, using a directing group (DG), might provide a convenient solution to their synthesis. However, this strategy usually results in partial cleavage of the directing group, preventing further/second C-H activation cascades. Herein we report a general strategy that allows for the precise control of the oxidation pathways so that directing groups can be either preserved or cleaved. We found that N-phenoxyacetamides could undergo ortho-arylation reactions with or without an external oxidant, yielding products with different oxidation states, notably the rare bis-arylated phenols. Notably, a unique rhodacycle intermediate was isolated, characterized by X-ray crystallography, and confirmed to be an active catalyst. Switching between internal and external oxidation could be a general strategy in diverse directed C-H functionalization reactions to realize bis-functionalized products.
- Wu, Qian,Chen, Ying,Yan, Dingyuan,Zhang, Muyue,Lu, Yi,Sun, Wei-Yin,Zhao, Jing
-
p. 169 - 173
(2016/12/28)
-
- Regioselective ortho-hydroxylation of 2-arylbenzothiazole via substrate directed C-H activation
-
An efficient protocol has been developed for the direct ortho-hydroxylation of 2-arylbenzothiazole using Pd(OAc)2 as the catalyst and either of DIB/AcOH or Oxone/TFA combinations under air atmosphere. Under both these conditions, the methodology tolerates a diverse array of substituents giving good to excellent yields of corresponding ortho-hydroxylated products. Regioselective hydroxylation is observed at the less sterically hindered site of the phenyl ring possessing substituents at its meta position.
- Banerjee, Arghya,Bera, Anupam,Guin, Srimanta,Rout, Saroj Kumar,Patel, Bhisma K.
-
p. 2175 - 2183
(2013/03/14)
-
- 2-(Benzothiazol-2-yl)-phenyl-β-d-galactopyranoside derivatives as fluorescent pigment dyeing substrates and their application for the assay of β-d-galactosidase activities
-
2-(Benzothiazol-2-yl)-phenyl-β-d-galactopyranoside derivatives were synthesized as novel artificial fluorescent pigment dyeing substrates for β-d-galactosidase. The substrates, which exhibited non-fluorescence or weak fluorescence in solution phase, were
- Otsubo, Tadamune,Minami, Akira,Fujii, Haruna,Taguchi, Risa,Takahashi, Tadanobu,Suzuki, Takashi,Teraoka, Fumiteru,Ikeda, Kiyoshi
-
supporting information
p. 2245 - 2249
(2013/05/08)
-
- An efficient synthesis of 2-substituted benzothiazoles in the presence of FeCl3/Montmorillonite K-10 under ultrasound irradiation
-
2-Substituted benzothiazoles have been synthesized via one-pot reaction from aromatic aldehydes and o-aminothiophenol in the presence of FeCl 3/Montmorillonite K-10 in absolute methanol at 25-30°C under ultrasound irradiation. The remarkable ad
- Chen, Guo-Feng,Jia, Hui-Ming,Zhang, Li-Yan,Chen, Bao-Hua,Li, Ji-Tai
-
p. 627 - 632
(2013/02/22)
-
- 2-(2'-Hydroxyphenyl)benzothiazoles, -benzoxazoles, and -benzimidazoles for Plastic Scintillation Applications
-
A new series of fluorescent compounds has been tested as dopants for plastic scintillation applications.Several 2-(2'-hydroxyphenyl)benzothiazole, -benzoxazole, and -benzimidazole derivative have been prepared and studied in a polystyrene matrix.Each deri
- Pla-Dalmau, Anna
-
p. 5468 - 5473
(2007/10/02)
-
- Solid-state Fluorescent Photophysics of Some 2-Substituted Benzothiazoles
-
The solid-state fluorescence properties of a series of benzothiazoles with phenyl, napthalene, and coumarin moieties substituted at the 2-position have been investigated.The necessity for a 2'-OH substituent for fluorescence has been confirmed and the effects of further substitution in the 2-phenyl ring are reported.
- Anthony, Kevin,Brown, Robert G.,Hepworth, John D.,Hodgson, Kevin W.,May, Bernadette,West, Michael A.
-
p. 2111 - 2118
(2007/10/02)
-