- FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
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A series of substituted fused tricyclic imidazole derivatives, in particular dihydro- 1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4- c']dipyridine, dihydro-1H-pyrano[3',4':4,5]imidazo[1,2-a]pyridine and tetrahydro-6H- cyc
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Page/Page column 111
(2015/06/25)
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- PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS
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Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein
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Page/Page column 55
(2009/05/29)
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- Single-step synthesis of cyclopentenones from (3-alkoxycarbonyl-2-oxopropylidene)triphenylphosphorane and 1,2-diacylethylenes
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(3-Alkoxycarbonyl-2-oxo-propylidene)triphenylphosphorane reacts with 1,2-diacylethylenes to give cyclopentenones in a single operation. Use of a chiral acylmethylenemalonate led to formation of optically active cyclopentenone in a highly diastereoselectiv
- Hatanaka,Ishida,Tanaka,Ueda
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p. 401 - 404
(2007/10/02)
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- NOVEL SYNTHESIS OF CARBOHYDRATES USING ELECTROREDUCTION AS KEY REACTIONS
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Glyceraldehyde was transformed to threose, erythrose, and erythrulose using electroreduction as key reactions.
- Shono, Tatsuya,Ohmizu, Hiroshi,Kise, Naoki
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p. 4801 - 4804
(2007/10/02)
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