PROTECTION OF 5'-TERMINAL PHOSPHATE OF DEOXYRIBOOLIGONUCLEOTIDES BY USE OF o,o'-DIAMINOBIPHENYL
Cyclic phosphorodianilidate derivatives of nucleoside 5'-phosphates were prepared by use of triphenylphosphine and 2,2'-dipyridyl disulfide as condensing agent and used for the synthesis of oligodeoxyribonucleotides.Removal of the diamino group was remarkably accelerated by coaddition of AgOAc and acid anhydrides to the conventional system, iAmONO-pyridine-AcOH.
Get Best Price for9054-18-6{(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-[(hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl)oxy]tetrahydrofuran-2-yl}methyl dihydrogen phosphate (non-preferred name)