cas 90734-98-8, 4-ethoxy-1H-indole-3-carbaldehyde | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
90734-98-8

Articles about 90734-98-8Total 3 be found

Article title
Article abstract
Author
Journal number and time
Download

1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
KDR kinase inhibition is considered to play an important role in regulating angiogenesis, which is vital for the survival and proliferation of tumor cells. Recently we disclosed a structure-based kinase inhibitor design strategy which led to the identification of a new class of VEGFR-2/KDR kinase inhibitors bearing heterocyclic substituted pyrazolones as the core template. Instability in a rat S9 preparation and poor iv PK profiles for most of these inhibitors necessitated exploration of new pyrazolones to identify new analogs with improved metabolic stability. Optimization of the heterocyclic moiety led to the identification of the thiadiazole series of pyrazolones (D) as potent VEGFR-2/KDR kinase inhibitors. SAR modifications, kinase selectivity profiling, and structural elements for improved PK properties were explored. Oral bioavailability up to 29% was achieved in the rat. Modeling results based on the Glide XP docking approach supported our postulation regarding the interaction of the lactam segment of the pyrazolones with the hinge region of the KDR kinase.
Tripathy, Rabindranath,Ghose, Arup,Singh, Jasbir,Bacon, Edward R.,Angeles, Thelma S.,Yang, Shi X.,Albom, Mark S.,Aimone, Lisa D.,Herman, Joseph L.,Mallamo, John P.
p. 1793 - 1798
(2007/10/03)

Photo-induced rearrangement of 1-ethoxy-2-phenylindole
Photoirradiation of 1-ethoxy-2-phenylindole in methanol afforded 3- and 6-ethoxy-2-phenylindoles. The structural determination of the latter is carried out by direct comparison of its spectral data with those of the authentic 4-, 5-, 6-, and 7-ethoxy-2-phenylindoles, whose syntheses are also included.
Yamada, Koji,Somei, Masanori
p. 2481 - 2484
(2007/10/03)

A PRACTICAL ONE POT SYNTHESIS OF 4-ALKOXY-3-FORMYLINDOLES
A simple and regioselective one pot synthetic method of 4-methoxy-, 4-benzyloxy, and 4-ethoxy-3-formylindoles from 3-formylindole is described.
Somei, Masanori,Yamada, Fumio,Kunimoto, Masako,Kaneko, Chikara
p. 797 - 801
(2007/10/02)

More Articles about upstream products of 90734-98-8

More Articles about downstream products of 90734-98-8

Chemical Properties

Melting Point: 124-126 °C(Solv: methanol (67-56-1))
Boiling Point: 381.8±22.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C
PKA: 15.79±0.30(Predicted)
PSA: 42.09000
LogP: 2.37910

Show more

Global suppliers and manufacturers of 90734-98-8total 9 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Hangzhou J&H Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:46
Country:

Win-Win chemical Co.Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:55
Country:

Hangzhou Sartort Biopharma Co., Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:80
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Bide Pharmatech Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

ENAO Chemical Co, Limited
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Debye Scientific
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 90734-98-8

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer