The Synthesis of Isotopically Labeled β-Adrenergic Agents by Reductive Amination: Unexpected Site of Deuterium Incorporation
The reduction of imines derived from the condensation of (R)-norepinephrine and certain methyl ketones with D2 over a Pt catalyst leads to the formation of deuterium labeled products in which the deuterium is located exclusively in the methyl substituent.
Asscher, Yael,Ferraiolo, Bobbe,Castagnoli, Neal
p. 3138 - 3141
(2007/10/02)
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