A novel synthesis of bicyclo[3.3.0]octane ring system via a desymmetric C-H insertion reaction
An optically active bicyclo[3.3.0]octane ring was synthesized by an intramolecular C-H insertion reaction. Upon treatment with a catalytic amount of Rh2(S-DOSP)4, a chiral-auxiliary-containing diazoester underwent a C-H insertion reaction to give the desired bicyclo[3.3.0]octane system. Georg Thieme Verlag Stuttgart.