- Discovery of imidazo[1,2-6]thiazole derivatives as novel SIRT1 activators
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A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. This series of compounds was derived from a high throughput scree
- Vu, Chi B.,Bemis, Jean E.,Disch, Jeremy S.,Ng, Pui Yee,Nunes, Joseph J.,Milne, Jill C.,Carney, David P.,Lynch, Amy V.,Smith, Jesse J.,Lavu, Siva,Lambert, Philip D.,Gagne, David J.,Jirousek, Michael R.,Schenk, Simon,Olefsky, Jerrold M.,Perni, Robert B.
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experimental part
p. 1275 - 1283
(2009/12/07)
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- SIRTUIN MODULATING IMIDAZOTHIAZOLE COMPOUNDS
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Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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- SIRTUIN POLYMORPHISMS AND METHODS OF USE THEREOF
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Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound andor subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage andor treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.
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Page/Page column 34-35
(2008/12/08)
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