cas 914223-27-1, tert-butyl 2-cyano-2-(5-nitropyridin-2-yl)acetate | Articles data ｜lookchem

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914223-27-1

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COMPOUNDS FOR MODULATING IL-17
The invention relates generally to compounds and their therapeutic use. More particularly, the invention relates to compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.
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Paragraph 00190

(2014/05/24)

FUSED HETEROARYLS AND THEIR USES
Provided are certain fused heteroaryls, compositions thereof and methods of use therefor.
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Paragraph 0146; 0147

(2013/07/31)

FUSED HETEROARYLS AND THEIR USES
Provided are certain fused heteroaryls, compositions thereof and methods of use therefor.
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Page/Page column 30

(2012/04/04)

Synthesis of 2-azastilbene derivatives with intramolecular charge transfer
The condensation reaction of 2-cyanomethyl-5-nitropyridine with aromatic aldehydes has been carried out with the aim of preparing 2-azastilbene derivatives having intramolecular charge transfer. The yield of the condensation products can be increased if the reaction is carried out in the medium used for obtaining the starting 2-cyanomethyl-5-nitropyridine without separating or purifying it. The electronic absorption spectra of the compounds show a charge-transfer band, the energy of which increases and the intensity falls with lowering of the electron-donor properties of the substituent in the 4-position. Introduction of the heteroatom into the acceptor part when changing from the stilbene to the 2-azastilbene system is accompanied by a decrease in the energy and increase in the intensity of the charge-transfer electronic transition.
Kokars,Yanishevskii,Kampars
p. 805 - 809
(2007/10/03)

Synthesis of Some Nitropyridylacetonitriles
A new synthesis of nitropyridylacetonitriles 4 has been developed, using tert-butyl cyanoacetate and the corresponding chloropyridines 2.The tert-butyl esters are removed by acid-catalyzed dealkoxycarbonylation.
Katz, R. B.,Voyle, M.
p. 314 - 316
(2007/10/02)

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Chemical Properties

Boiling Point: 401.8±45.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C
PKA: 6.40±0.29(Predicted)
PSA: 108.80000
LogP: 2.46188

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