- Preparation method of lorlatinib intermediate compound
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The invention relates to a preparation method of a lorlatinib intermediate compound. 4-fluoroacetanilide is taken as a raw material and carry out visible light Fries rearrangement in the presence of avisible light catalyst and visible light to obtain an i
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Paragraph 0033; 0037-0042; 0043; 0046-0047
(2020/04/06)
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- Palladium-Catalyzed Alkylation with Alkyl Halides by C(sp3)?H Activation
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Utilizing halogens as traceless directing goups represents an attractive strategy for C?H functionalization. A two C?H alkylation system, initiated by the oxidative addition of organohalides to Pd0, has been developed. The first reaction involves an intermolecular alkylation of palladacycles to form C(sp3)?C(sp2) bonds followed by C(sp2)?H activation/cyclization to deliver alkylated benzocyclobutenes as the final products. In the second reaction, two C?C bonds are formed by the reaction of palladacycles with CH2Br2, and provides a facile and efficient method for the synthesis of indanes. The alkylated benzocyclobutene products can be transformed into tricyclic hyrocarbons, and the indane derivatives are essential structural motifs in bioactive and odorant molecules.
- Wu, Zhuo,Ma, Ding,Zhou, Bo,Ji, Xiaoming,Ma, Xiaotian,Wang, Xiaoling,Zhang, Yanghui
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p. 12288 - 12291
(2017/09/06)
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- Preparation method of 1-(5-fluoro-2-iodophenyl)ethanone
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The invention relates to a preparation method of 1-(5-fluoro-2-iodophenyl)ethanone.According to the method, 2-amino-5-fluorobenzoic acid and 5-fluoro-2-iodobenzoic acid react to prepare the final product 1-(5-fluoro-2-iodophenyl)ethanone.The method is sim
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Paragraph 0024; 0030; 0034
(2017/03/17)
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