- Nitrogen-containing heterocyclic compound and medicinal composition and application thereof
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The invention provides a nitrogen-containing heterocyclic compound with a structure represented by a formula I, or a pharmaceutically acceptable salt, a stereoisomer or a prodrug molecule thereof, and a pharmaceutical composition and application thereof. The compound and the pharmaceutically acceptable salt thereof have an inhibition effect on RIOK2 protease, can effectively inhibit the growth of various tumor cells, and can be used for preparing antitumor drugs.
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- Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M
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The covalent binding nature of irreversible kinase inhibitors potentially increases the severity of “off-target” toxicity. Based on our continual strategy of chemically tuning the Michael addition acceptors, herein, we further explore the relationship amo
- Chen, Wenteng,Liu, Shuangrong,Liu, Xingyu,Pan, Youlu,Shao, Jiaan
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