- Method for purifying flurbiprofen axetil
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The invention discloses a method for purifying flurbiprofen axetil, a high-pressure preparation method is applied to a flurbiprofen axetil purification process for the first time, and a flurbiprofen axetil purification process which is efficient, stable and easier for industrial production is developed.
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Paragraph 0019-0025
(2021/11/14)
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- Preparation method of flurbiprofen and preparation method of flurbiprofen axetil
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The invention relates to the field of pharmaceutical chemical synthesis, in particular to a preparation method of flurbiprofen and a preparation method of flurbiprofen axetil. The preparation method of the flurbiprofen comprises the steps of carrying out a Grignard reaction by using 4-bromine-2-fluorine biphenyl as a raw material, carrying out a coupling reaction, and acidizing to obtain the flurbiprofen; the yield is 90%, and the purity is 99.5%; then, the flurbiprofen axetil is prepared by using the flurbiprofen, obtained by the method, as a raw material, the yield reaches up to 90%, and thepurity reaches up to 99.5%. The preparation methods are high in quality controllability and industrial reproducibility.
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