Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids
The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine β3 adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model
Shearer, Barry G.,Chao, Esther Y.,Uehling, David E.,Deaton, David N.,Cowan, Conrad,Sherman, Bryan W.,Milliken, Tula,Faison, Walter,Brown, Kathleen,Adkison, Kimberly K.,Lee, Frank
p. 4670 - 4677
(2008/02/12)
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configu
Baumann, Marcus,Baxendale, Ian R.,Ley, Steven V.,Smith, Christoper D.,Tranmer, Geoffrey K.
p. 5231 - 5234
(2007/10/03)
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