Antispasmodic and antimicrobial activities of pyrazole-containing ferrocenyl alkanols versus their phenyl analogs, and the entry point to potential multitarget treatment for inflammatory bowel diseases
Inflammatory bowel diseases (IBM), such as Crohn's disease, and their common complications represent a global health challenge. Many pyrazole derivatives, such as the spasmolytic drug metamizole, have already found their place among the frequently used th
Radulovi?, Niko S.,Nikoli?, Milica G.,Mladenovi?, Marko Z.,Ran?elovi?, Pavle,Stojanovi?, Nikola M.,Stojanovi?-Radi?, Zorica,Jovanovi?, Ljiljana
(2021/11/23)
Reductive amination of ferrocenylformylpyrazoles
1-Aryl-3-ferrocenyl-4-formylpyrazoles were obtained from appropriate acetylferrocene arylhydrazones by the Vilsmeier-Haack reaction. Direct reductive amination of the resulting aldehydes with primary and secondary amines and amino acid esters in the prese