ASYMMETRIC INDUCTION IN THE CYCLOADDITION REACTION OF DICHLOROKETENE WITH CHIRAL ENOL ETHERS. A VERSATILE APPROACH TO OPTICALLY ACTIVE CYCLOPENTENONE DERIVATIVES.
Significant asymmetric induction has been observed in the cycloaddition reaction of dichloroketene with chiral enol ethers.The resultant diastereomeric cyclobutanones have been converted to synthetically useful α-chlorocyclopentenones in optically active form.
Greene, Andrew E.,Charbonnier, Florence
p. 5525 - 5528
(2007/10/02)
STRATEGY FOR CYCLOPENTENONE ANNULATION OF OLEFINS: A GENERAL PROTOCOL FOR BICYCLOENONE SYNTHESIS
Several bicyclic α-chloro enones obtained through Greene annulation of cyclic olefins are shown to undergo efficient, two step, enone transposition via Luche reduction and aq. formic acid treatment.Application of this methodology to the formal synthesis of exaltone and (+/-)-muscone is described.
Mehta, Goverdhan,Rao, K. Srinivas
p. 1839 - 1842
(2007/10/02)
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