5-6-BICYCLIC HETEROAROMATIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
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Page/Page column 70
(2009/04/25)
Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex
The prevention of cell death by the antiapoptotic protein Bcl-xL has been linked to a number of cancers. Bcl-xl binds to the BH3 domain of the proapoptotic protein Bak, thus preventing programmed cell death. A competitive assay and docking studies have shown that the polyamide scaffold 1, which was synthesized based on a rational structure-based design, interferes with the Bak BH3/Bcl-xl complexation.
Ernst, Justin T.,Becerril, Jorge,Park, Hyung Soon,Yin, Hang,Hamilton, Andrew D.
p. 535 - 539
(2007/10/03)
Proteomimetic compounds and methods
The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.
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(2008/06/13)
Synthesis of new pyridine intermediates as precursors for the elaboration of streptonigrin analogues by the metalation-cross-coupling strategy
Starting from available 2-amino-6-chloro-3-nitropyridine, synthesis of 3-amino-6-pyridinecarboxylic acid derivatives precursor for pyridine ring C of streptonigrin analogues is described.
Pomel,Rovera,Godard,Marsais,Queguiner
p. 1995 - 2005
(2007/10/03)
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