- Platelet activating factor derivative and synthesis method thereof
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The invention belongs to the technical field of chemical synthesis and discloses a platelet activating factor derivative with a formula (I) structure, wherein a substituent group R refers to an acryl group. A synthetic route includes nine-step reaction by taking chiral source S-configuration solketal as a starting reactant. The method is adopted for synthesis of a 2-sulfo platelet activating factor and a derivative thereof for the first time and has advantages of high yield, easiness in separation and the like. Low-cost batch synthesis of 2-S-PAF and the derivative thereof is realized, and significances to activity research of 2-S-PAF and the derivative thereof, biological experiments, clinical application and disease treatment are achieved.
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Paragraph 0035; 0043; 0044
(2017/08/29)
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- Method for preventing cancer metastasis
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The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.
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- Structure and synthesis of a unique isonitrile lipid isolated from the marine mollusk actinocyclus papillatus
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The first chemical study of an Actinocyclidae nudibranch, Actinocyclus papillatus, resulted in the isolation of (-)-actisonitrile (1), a lipid based on a 1,3-propanediol ether skeleton. The structure was established by spectroscopic methods, whereas the a
- Manzo, Emiliano,Carbone, Marianna,Mollo, Ernesto,Irace, Carlo,Di Pascale, Antonio,Li, Yan,Ciavatta, Maria Letizia,Cimino, Guido,Guo, Yue-Wei,Gavagnin, Margherita
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supporting information; experimental part
p. 1897 - 1899
(2011/06/21)
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- OXIDIZED LIPID COMPOUNDS AND USES THEREOF
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Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.
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Page/Page column 57
(2010/06/11)
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- OXIDIZED THIOPHOSPHOLIPID COMPOUNDS AND USES THEREOF
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Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: (I) wherein X1, X2, A1, A2, B', B'', D' and D'' are as described herein.
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Page/Page column 61
(2010/04/28)
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- Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
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Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.
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- An efficient synthesis of Platelet-Activating Factor (PAF) via 1-o-alkyl-2-o-(3-isoxazolyl)-SN-glycero-3-phosphocholine, a new PAF agonist utilization of the 3-isoxazolyloxy group as a protected hydroxyl
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Potent PAF agonists (R)-3a,b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy gro
- Nakamura, Norio,Miyazaki, Hideki,Ohkawa, Nobuyuki,Oshima, Takeshi,Koike, Hiroyuki
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p. 699 - 702
(2007/10/02)
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