Synthesis of a novel antiretroviral thymidine analog: 1-(2-deoxy-β-D- ribofuranosyl)-4-acetylimidazolin-2-one (imidine)
The total synthesis of imidine (8), a novel isomer of thymidine is described. Depending on the coupling method used, either the anomeric mixture of the protected desired nucleoside, or the positional isomer 14 is obtained.
THE REACTION OF 5-ACETYL-2-AMINOOXAZOLE WITH AMINES: AN APPROACH TO 1H-5-ACETYL-2-AMINOIMIDAZOLES
5-Acetyl-2-aminooxazole, upon treatment with amines in the presence of water, affords good yields of 1H-5-acetyl-2-substituted aminoimidazoles, along with varying amounts of the corresponding 5-hydroxy-4-methyl-2-substituted aminopyrimidines.
LaMattina, John L.,Mularski, Christian J.
p. 2957 - 2960
(2007/10/02)
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