2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11β-hydroxysteriod dehydrogenase type 1
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme that converts cortisone to cortisol. A growing body of evidence suggests that selective inhibition of 11β-HSD1 could potentially treat metabolic syndrome as well as type 2 diabetes. Through
St. Jean Jr., David J.,Yuan, Chester,Bercot, Eric A.,Cupples, Rod,Chen, Michelle,Fretland, Jenne,Hale, Clarence,Hungate, Randall W.,Komorowski, Renee,Veniant, Murielle,Wang, Minghan,Zhang, Xiping,Fotsch, Christopher
p. 429 - 432
(2007/10/03)
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