benzodiazepinederivativesof formula(Ie) whereinoneofr1 andr2 isa benzodiazepinyl-containing groupof formula(II) in whichr8 is Hor halo;theotherofr1andr2 isa group Z selected from H,C3-C6 cycloalkyl,halo,-NHR9,benzyl,phenyl,4-to 10-membered heterocyclyland 4-to 10-membered heteroaryl,whereinphenyl,heterocyclyland heteroarylare unsubstitutedor substituted byoneortwo substituents selected from 4-to 10-membered heterocyclyl which is unsubstitutedor substituted byoR,and from C1-C6alkyl,C1-C6 hydroxyalkyl,C1-C6 haloalkyl,C3-C6 cycloalkyl,halo,-OR,-(ch2)mOR,-NR2,-(ch2)mNR2,-NHR",-SOmNR2,-SOmR,-SR,nitro,-CO2R,-CN,-CONR2,-NHCOR,-ch2NR10R11and-NR10R11,in whicheachr is independently Hor C1-C6alkyl,r" is C3-C6 cycloalkyland m is 1or 2;r9 is selected fromphenyland 4-to 10-membered heteroaryl whereinphenyland heteroarylare unsubstitutedor substituted by halo;r10 andr11areeach independently Hor C1-C6alkyl;orr10andr11 form,together withthenatomto whichtheyareattached,either(a)a morpholinering which isoptionally bridged bya-ch2-group linkingtworing carbonatomsthatarepositionedparatoeachother,or(b)a spiro groupofthe following formula(b):andringa isaringofoneofthe following structural formulae(I-1),(I-2)and(I-3):andringa isaringofoneofthe following structural formulae(I-1),(1-2)and(1-3): in which Y is selected fromo,S,SO2and NR,whereinr isasdefinedabove,andeachofr2tor7 is independently H,C1-C6alkyl,C1-C6 hydroxyalkyl,C3-C6 cycloalkyl,halo,-OR,-ch2OR,-NR2,-ch2NR12R13,-NRCOOR,-ch2OR,-SOmNR2,-SOmR,-ch2SOmR,nitro,-CO2R,-CN,-CONR2or-NHCOR,in whichrand mareasdefinedaboveandr12andr13areeach independently H,C1-C6alkyl,benzyl,4-to 10-membered heterocyclylorr12andr13 form,together withthenatomto whichtheyareattached,a 4-to 10-membered heteroaryl which is unsubstitutedora 4-to 10-membered heterocyclyl which is unsubstitutedor substituted with C1-C6alkylor halo,oranytwoofr2tor7that bondtothe same carbonatom forma spiroring selected froma C3-C6 cycloalkyl spiroringanda spirooxetaneringofthe following structure:(Formulaa)andthepharmaceuticallyacceptable saltsthereofare inhibitorsofrSVand cantherefore be usedtotreatorpreventanrSV infection.