Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/ β-galactosylceramides
Two novel hybrid molecules 3-O-sulfo-α/β-galactosylceramide 3 and 4, which are derived from an immunostimulatory agent α-GalCer 1 and self-glycolipid ligand sulfatide 2, were designed and synthesized. Compound 3 was shown to efficiently stimulate human NK
Xing, Guo-Wen,Wu, Douglass,Poles, Michael A.,Horowitz, Amir,Tsuji, Moriya,Ho, David D.,Wong, Chi-Huey
GLYCOLIPIDS AND ANALOGUES THEREOF AS ANTIGENS FOR NK T CELLS
This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
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Page/Page column 75-76; 4/23
(2008/06/13)
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