- Pyridazino quinoline compounds
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The invention relates to pyridazinoquinoline compounds of the formulas B and B′ wherein Ring A is selected from an ortho fused aromatic or heteroaromatic five- or six-membered ring and R1, R3and R4are substituents selected from halo, OH, OCF3, NO2, CN, NR′R″, SO2NR′R″, SOmR′alkyl, and a variety of alkyl, aryl, heterocyclic and heteroaryl groups, to pharmaceutical compositions containing them and to methods utilizing them for the treatment of neurological disorders.
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- Pyridazino quinoline compounds
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The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula II in the treatment and/or prevention of certain diseases or conditions. In formula II A is chosen from ortho substituted aryl or heteroaryl
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- Pyridazion quinoline compounds
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The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula (I) in the treatment and/or prevention of certain diseases or conditions. In formula (I), A is chosen from ortho substituted aryl or heteroaryl species, X is chosen from --OH, --SH, NHR and R 1 or R 2 is chosen from --(CH 2) n L wherein L may be selected from a variety of substituents including aryl, heteroaryl and heterocyclic groups. The compounds are useful in treating and/or preventing neurological disorders associated with excitatory amino acids. STR1
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- The synthesis of phenylhydrazines from bis(2,2,2-trichloroethyl) azodicarboxylates and electron-rich arenes
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Phenylhydrazines are readily prepared in a two step sequences using electron rich arenes molecules and bis(2,2,2 trichloroethyl) azodicarboxylate (BTCEAD).
- Dufresne, Claude,Leblanc, Yves,Berthelette, Carl,McCooeye, Chris
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p. 3613 - 3624
(2007/10/03)
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- Tetrahydroindenoindole compounds useful in the treatment of conditions associated with free radical formation
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The invention concerns compounds and their enantiomers of the formula IA or IB STR1 and pharmaceutically acceptable salts thereof wherein each of R1, R2, R3, R4, R6, R7, R8, R9, R10, R11 and R12 is independently selected from hydrogen or an alkyl group containing 1-6 carbon atoms and R5 is an alkoxy group containing 1-6 carbon atoms. The invention further concerns pharmaceutical compositions comprising the active compounds and methods employing the compounds for the treatment of conditions associated with free radical formation.
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- Synthesis of 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives as possible nonsteroidal cardiotonics
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New substituted 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives 19-29 and 34-43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 (2-(2,3-dimethoxybenzylamino)-N-(3,3,7-trimethyl-2-oxo-2,3-dihydro-1H-i ndol-5-yl)acetamide) showed very potent activity.
- Lee,Huang,Lin,Shih,Lee,Lin
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