- CYCLIC COMPOUNDS AND METHODS OF USING SAME
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The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.
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Page/Page column 177-178
(2021/07/02)
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- Applications of 2-Chloro-3,3,3-trifluoroprop-1-ene (HCFO-1233xf): A Rapid Entry to Various β-Substituted-trifluoromethyl-ethenes
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An efficient base-promoted reaction of O-, N-, and S-nucleophiles with 2-chloro-3,3,3-trifluoprop-1-ene (HCFO-1233xf) is described providing access to various β-substituted-trifluoromethyl-ethenes under mild reaction conditions. Mechanistic investigations shed some light on the regio-, chemo-, and stereoselectivities observed. The olefins prepared represent attractive intermediates in chemical discovery: Some applications include their conversion to pyrrolidines via a [3 + 2] dipolar cycloaddition reaction. These weakly basic amines represent novel synthons that could be readily elaborated through a range of reactions.
- El Qacemi, Myriem,Meyer, Daniel
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supporting information
p. 3479 - 3484
(2020/04/21)
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- Reaction of substituted phenols and alcohols with (E)-1-chloro-3,3,3-trifluoropropene (HFCO-1233zd)
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Simple and convenient one-pot procedures for the preparation of ArOCH=CHCF3, ROCH=CHCF3 and CF3CH=CHOArOCH = CHCF3 starting from the industrial product HFCO-1233zd (CF3CH=CHCl) are presented. These syntheses involve the reaction of 1233zd with phenols and alcohols in the presence of potassium hydroxide in DMF or pyridine solvent at elevated temperatures.
- Filatov, Andrey A.,Kremlev, Mikhail M.,Mushta, Oleksii ?.,Yagupolskii, Yurii L.
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- METHOD FOR PRODUCING 3,3,3-TRIFLUOROPROPANOL
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PROBLEM TO BE SOLVED: To provide a method for producing 3,3,3-trifluoropropanol efficiently on an industrial scale. SOLUTION: 3,3,3-trifluoropropanol is produced by the reaction between benzyl vinyl ether represented by the following formula [where R is a phenyl group, or a phenyl group having a substituent represented by R1 (where R1 is an alkyl group, an alkoxy group, a halogen atom or a nitro group)] and hydrogen (H2) in the presence of a palladium catalyst. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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Paragraph 0035-0036
(2018/01/09)
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- PROCESS FOR PRODUCING 3,3,3-TRIFLUOROPROPIONIC ACID
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A benzyl vinyl ether represented by the following formula is hydrolyzed in the presence of a catalyst selected among Arrhenius acids and Lewis acids to obtain 3,3,3-trifluoropropionaldehyde. Subsequently, the 3,3,3-trifluoropropionaldehyde is oxidized with an oxidizing agent. Thus, 3,3,3-trifluoropropionic acid can be more advantageously produced than in conventional techniques from an inexpensive starting material.
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Page/Page column 14
(2008/12/07)
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- PROCESS FOR PRODUCING 3,3,3-TRIFLUOROPROPIONALDEHYDE
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A process for producing 3,3,3-trifluoropropionaldehyde which comprises hydrolyzing a benzyl vinyl ether represented by the formula [1]: (wherein R represents phenyl or phenyl substituted by R1 (R1 represents a member selected among alkyl, alkoxy, halogeno, and nitro)) in the presence of a catalyst selected among Arrhenius acids and Lewis acids.
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Page/Page column 16-18
(2008/06/13)
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