- Enantioselective Construction of Chiral 2,3-cis-Dimethyldihydrobenzofuran with an All-Carbon Quaternary Center: An Efficient Approach to (+)/(-)-PI-220 and (+)-3-epi-Furaquinocin C
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A new strategy for the enantioselective construction of chiral 2,3-cis-dimethyldihydrobenzofurans has been developed by a ruthenium-catalyzed asymmetric hydrogenation of racemic α-aryloxybutanone via dynamic kinetic resolution (DKR), combined with a palladium-catalyzed intramolecular reductive Heck cyclization. Starting from optically active 2,3-cis-dimethyldihydrobenzofuran, the natural products (+)/(-)-PI-220 and (+)-3-epi-furaquinocin C were synthesized in high yields.
- Pu, Liu-Yang,Chen, Ji-Qiang,Li, Mao-Lin,Li, Yao,Xie, Jian-Hua,Zhou, Qi-Lin
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- Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death
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Chagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making this class of compounds appealing for drug development. Previously, the hom
- Magalhaes Moreira, Diogo Rodrigo,De Oliveira, Ana Daura Travassos,Teixeira De Moraes Gomes, Paulo André,De Simone, Carlos Alberto,Villela, Filipe Silva,Ferreira, Rafaela Salgado,Da Silva, Aline Caroline,Dos Santos, Thiago André Ramos,Brelaz De Castro, Maria Carolina Accioly,Pereira, Valéria Rego Alves,Leite, Ana Cristina Lima
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p. 467 - 478
(2014/03/21)
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- Dihydrothienopsoralens: New furocoumarins as potential photoreacting agents
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A series of new dihydrothienopsoralen derivatives were synthesized from 6-hydroxybenzo[b]furan in four steps in good yield. These compounds were prepared as potential photosensitizing and chemotherapeutic agents for psoriasis. The spectroscopy study in al
- Zoubir,Refouvelet,Aubin,Humbert,Xicluna
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p. 509 - 513
(2007/10/03)
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- Dimethyldioxirane epoxidation of benzofurans: Reversible thermal and photochemical valence isomerization between benzofuran epoxides, quinone methides, and benzoxetenes
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Low-temperature oxidation of the four possible regioisomeric methoxy-substituted benzofurans 1 by dimethyldioxirane afforded the rather labile epoxides 2, which are in equilibrium with their equally labile quinone methides 3 through reversible valence iso
- Adam, Waldemar,Hadjiarapoglou, Lazaros,Peters, Karl,Sauter, Markus
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p. 8603 - 8608
(2007/10/02)
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