Catalytic enantioselective synthesis of flavanones and chromanones
Various chromanone, flavanone and abyssinone compounds as can be prepared enantioselectively using a chiral thiourea catalyst.
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Page/Page column 16
(2009/10/21)
Catalytic enantioselective synthesis of flavanones and chromanones
The enantioselective synthesis of flavanones and chromanones is described. Bifunctional thiourea catalysts promote an asymmetric oxo-conjugate addition to a β-ketoester alkylidene in high yields with excellent enantioselectivity (80-94% ee) for aryl and alkyl substrates. Decarboxylation of the β-ketoester proceeds smoothly in a one-pot procedure to afford the enantioenriched flavanones and chromanones. Copyright
Biddle, Margaret M.,Lin, Michael,Scheidt, Karl A.
p. 3830 - 3831
(2008/02/04)
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