Magnolia extract, magnolol, and metabolites: Activation of cannabinoid CB2 receptors and blockade of the related GPR55
The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that the extract and its main bioactive constituents, magnolol and honokiol, can activate cannabinoid
Rempel, Viktor,Fuchs, Alexander,Hinz, Sonja,Karcz, Tadeusz,Lehr, Matthias,Koetter, Uwe,Müller, Christa E.
supporting information
p. 41 - 45
(2013/03/13)
Enantioselective syntheses of (S)- and (R)-8,9 dihydroxydihydromagnolol
8,9-Dihydroxydihydromagnolol 5 was synthesized in four steps in which the synthesis of magnolol 4 was improved and the absolute configuration of 5 was confirmed as (R).