From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties
Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines. Copyright
Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues
We have recently reported that a series of (E)-8-styrylcaffeines and (E)-2-styrylbenzimidazoles are moderate to very potent competitive inhibitors of monoamine oxidase B (MAO-B). The most potent member of the series was found to be (E)-8-(3-chlorostyryl)c
van den Berg, Deidre,Zoellner, Kevin R.,Ogunrombi, Modupe O.,Malan, Sarel F.,Terre'Blanche, Gisella,Castagnoli Jr., Neal,Bergh, Jacobus J.,Petzer, Jacobus P.
p. 3692 - 3702
(2008/02/07)
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