- Method for green synthesis of simvastatin side chain (by machine translation)
-
The method, comprises the following steps, adding :(1) dimethyl butanoic acid 2,2 - thionyl chloride, to the reaction vessel in a pot method, to carry out the esterification reaction ;(2) to obtain the product (1) dimethyl - 1 1-oxobutyl 3 -methyl propionate, through a solventless method, thereby reducing the material cost 3 - [(2,2 - without using any acid-binding agent) in the esterification step] and reducing the pollution, to the environment by a one-pot, method, at the same time without using any acid-tie-acid-acid-tie-acid-acid methyl ester, to carry out esterification reaction in a solvent concentration step, in the, esterification step by using a solventless method in a step, in the esterification reaction step, to obtain the, product (dimethyl) chloride, in the esterification step. (by machine translation)
- -
-
Paragraph 0024-0029
(2020/04/17)
-
- Preparation method for reducing production cost of alpha-dimethylbutyryl-S-methyl propionate
-
The invention discloses a preparation method for reducing the production cost of alpha-dimethylbutyryl-S-methyl propionate. The preparation method comprises the following steps: 1, adding 2,2-dimethylbutanoyl chloride to a reaction container, adding an organic solvent to the reaction container in a dropwise manner, stirring and cooling, and adding methyl 3-mercaptopropionate to the reaction container; 2, introducing ammonia to the reaction container when materials to be reacted in the container are cooled to 0DEG C; 3, adding water to the above reaction container after the reaction ends to make hydrogen chloride generated after the reaction be dissolved in water, and standing for layering; 4, obtaining a water layer and an organic layer after liquid layering, recovering the water solution of the water layer, and distilling to recover the organic solvent and obtain a crude product; and 5, heating the crude product to concentrate the crude product in order to obtain a mixture, filtering the mixture, washing the filtered mixture, and drying the washed mixture to obtain the above product. The method has the advantages of simplicity, easy obtaining and low price of raw material, high purity and yield of the product, and easy industrial production.
- -
-
Paragraph 0031-0034; 0036-0038; 0040-0042; 0044-0046
(2018/02/04)
-
- Lov-D acyltransferase mediated acylation
-
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
- -
-
Page/Page column 23
(2016/08/17)
-