Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus
As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen-Schmidt aldol condensation reaction. The new
Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
Compounds of the formula STR1 wherein one of R and Ro is STR2 and the other is primary or secondary C1-6 alkyl not containing an asymmetric carbon atom, C3-6 cycloalkyl or phenyl(CH2)m --, wherein Rs
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(2008/06/13)
2-FORMYLATION OF 3-ARYLINDOLES
The preparation of N-substituted-3-(4-fluorophenyl)indoles (R = H, CH3, i-Pr) and their direct formylation at the 2-position by Vilsmeier-Haack or Friedel-Crafts methodologies is described.
Walkup, R. E.,Linder, J.
p. 2155 - 2158
(2007/10/02)
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