Renewable amberlyst-15 catalyzed highly regioselective tritylation and deprotection of sugar-based diols
Amberlyst-15 catalyzed highly regioselective tritylation of sugar-based diols was achieved under mild condition using 4,4′-dimethoxytrityl alcohol (DMTrOH). Deprotection of the corresponding DMTr group was also established by the variation to protic solvent. Meanwhile, the heterogeneous catalyst Amberlyst-15 was recycled 3 times with satisfactory retention of catalytic activity and proved its potential application in industry.
δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase
The replacement of the pyrophosphate moiety of 2′-deoxynucleoside triphosphates by non natural δ-dicarboxylic butyl amino acid allows incorporation of natural 2′-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3′-
INHIBITORS OF RNA DEPENDENT RNA POLYMERASE AND USES THEREOF
The invention herein provides novel viral DNA polymerase compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with viral DNA polymerase activity, and processes and intermediates useful for preparing such compounds.
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Page 24
(2008/06/13)
Nucleotide libraries as a source of biologically relevant chemical diversity: Solution-phase synthesis
Solution-phase parallel synthesis of nucleotide library 1 consisting of 150 members is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
Zhou, Wenqiang,Upendran, Sathya,Roland, Arlene,Jin, Yi,Iyer, Radhakrishnan P.
p. 1249 - 1252
(2007/10/03)
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