- COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
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The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Page/Page column 96; 101
(2014/01/09)
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- Bioactive taxoids from Japanese yew Taxus Cuspidata and taxol biosynthesis
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A series of new taxoids, named taxuspines A ~ H and J ~ Z (1 ~ 25), have been isolated together with 37 known taxoids (26 ~ 62) including taxol (42) from the Japanese yew Taxus cuspidata Sieb. et Zucc. These new taxoids possessed various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl2-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids as well as recent development of taxol biosynthesis.
- Kobayashi, Jun'ichi,Shigemori, Hideyuki
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p. 1111 - 1133
(2007/10/03)
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