- 2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE
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The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.
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- THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS
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The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
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Page/Page column 26
(2008/06/13)
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- IMIDAZOPYRIDAZINE COMPOUNDS
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The present invention relates to novel substituted imidazo[1,2-b] pyridazine compounds of Formula (I) pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.
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Page/Page column 89-90
(2008/06/13)
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- Chemistry of Thienopyridines. XXXI. A New Synthesis of Thienopyridine and Studies on Direct Substitution into Its Thiophene Ring
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Thienopyridine (1) is synthesized in 65percent overall yield for two steps which consist of addition of toluene-α-thiol to 2-ethynylpyridine plus vacuum pyrolysis of the addend (7).Cis and trans forms of 7 are described.Compound 1 undergoes (a) ele
- Klemm, L. H.,Louris, John N.
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p. 785 - 790
(2007/10/02)
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