Use of Hypervalent Iodine Oxidation for the C(3)-Hydroxylation of Chromone, Flavone and α-Naphthoflavone
C(3)-Hydroxylation of chromone (1a), flavone (1b) and α-naphthoflavone (4) via acid-catalysed hydrolysis of the corresponding β-methoxy-α-hydroxydimethylacetals (2a, 2b, and 5) formed by iodobenzene diacetate-potassium hydroxide methanol oxidation is described.
Moriarty, Robert M.,Prakash, Om,Musallam, H. A.
p. 583 - 584
(2007/10/02)
Hypervalent Iodine Oxidation of α,β-Unsaturated Ketones: Chromone, Flavone, Chalcone, and Flavanone
Reaction of the title compounds with PhI(OAc)2 and MeOH-KOH leads to α-hydroxydimethylacetal β-methoxy products regiospecifically and stereospecifically, as demonstrated by X-ray diffraction.
Moriarty, Robert M.,Prakash, Om,Freeman, Wade A.
p. 927 - 929
(2007/10/02)
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