Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes
A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.
Trichlorotitanium dialkylamino-alkoxides (2; titanates of N,O-hemiacetals) are generated either from the corresponding lithium alkoxides and titanium tetrachloride (Scheme I) or by addition of trichloro-dialkylamino-titanium to aldehydes.The electrophilic
Seebach, Dieter,Betschart, Claudia,Schiess, Martin
p. 1593 - 1597
(2007/10/02)
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