The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties
Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties.
Imbriglio, Jason E.,Dirocco, Daniel,Bodner, Rena,Raghavan, Subharekha,Chen, Weichun,Marley, Daria,Esser, Craig,Holt, Tom G.,Wolff, Michael S.,Taggart, Andrew K.P.,Waters, M. Gerard,Tata, James R.,Colletti, Steven L.