Titanium-catalyzed hydroamination of propargyl alcohol derivatives: Synthesis of 3-silyloxy-2-methylindoles via hydrohydrazination
A general method for the one-pot synthesis of substituted 3-(tert-butyldimethylsilyloxy)indoles via hydrohydrazination of alkynes and subsequent Fischer indole synthesis has been developed. For the first time titanium-catalyzed hydroaminations of propargy
Substituted indole sulfonamide compounds, their preparation and use as medicaments
The present invention relates to substituted indole sulfonamide compounds of general formula(I), a process for their preparation, a medicament comprising these compounds and the use of substituted indole sulfonamide compounds for the preparation of medica
-
Page/Page column 35-36
(2008/12/07)
Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT 6 receptor ligands
The synthesis of new pharmaceutically interesting 3-(2-N,N- diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield.