PHARMACEUTICAL PREPARATIONS OF CRYSTALLINE LAZABEMIDE
Pharmaceutical compositions of lazabemide HCl crystalline Form A are disclosed along with methods of their production.
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(2008/06/13)
PROCESS FOR PREPARING PYRIDINE-2-CARBOXAMIDES AND INTERMEDIATES THEREFOR
A process for the preparation of pyridine-2-carboxamide compounds and intermediate compounds in the process are disclosed. The process involves reaction of a 2-cyano-5-halopyridine with 1,2-diaminoethane to produce a 2-(5-halopyridine-2-yl)-1H-imidazoline intermediate. This is followed by hydrolysis of the intermediate to produce a N-(2-aminoethyl)-5-halo-2-pyridinecarboxamide free base and, if desired, preparation of the acid addition salt thereafter.
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(2008/06/13)
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