- Novel use of amine compounds
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The invention provides a preparation method and novel use of amine compounds. Specifically, the invention provides compounds shown in the formula A or their optical isomers, racemes, solvates or pharmaceutically acceptable salts and a medical use thereof. The above compounds can be used for preparation of a pharmaceutical composition or a preparation. The pharmaceutical composition or preparationis used for (a) inhibiting a transient receptor potential channel protein TRPA1 and (b) treating diseases associated with the transient receptor potential channel protein, wherein each group is defined in the specification.
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Paragraph 0159; 0160; 0161; 0162
(2018/06/28)
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- Deuterated optical isomer and medical application thereof
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The invention provides compounds as shown in structural formulae Ia and Ib, non-toxic pharmaceutically-acceptable salts of the compounds and applications of the compounds to preparation of drugs fortreating depression. In a formula I, R1, R2, R3, R4, R5, R6, R7 and R8 are independently H or deuterium (D); and meanwhile, at least one of R1, R2, R3, R4, R5, R6, R7 and R8 is D.
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Paragraph 0010; 0013; 0014
(2019/01/08)
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- Optical isomer and medical use thereof
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The invention relates to optical isomers shown in formula Ia and Ib, i.e. (R)-N-methyl-3-[(benzo[1,3]dioxolane-4-yl)oxo]-3-(thiophene-2-yl)-propylamine and (S)-N-methyl-3-[(benzo[1,3]dioxolane-4-yl)oxo]-3-(thiophene-2-yl)-propylamine, pharmaceutically acceptable salts thereof, pharmaceutical composition containing the optical isomers shown in formula Ia or Ib and pharmaceutically acceptable salts thereof as active ingredients and application of the pharmaceutical composition as antidepressant drug.
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Paragraph 0020-0021
(2017/06/29)
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- 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES
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6-Amino-5-halo-4-pyrirnidinecarboxylic acids having poly-substituted aryl substituents in the 2-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.
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Page/Page column 31
(2008/06/13)
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- 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides
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4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.
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Page/Page column 11
(2008/06/13)
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