The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
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Page/Page column 21; 150
(2020/09/18)
Catalytic hydrogenation of 3-amino-6-(trifluoromethyl)-5,6-dihydropyridin- 2(1 H)-ones and its use in the synthesis of trifluoromethyl-containing mimetics of ornithine and thalidomide
A series of 3-amino-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-ones and 6-hydroxy-5,6-dihydropyridin-2(1H)-ones were hydrogenated to give the corresponding piperidinones. These lactams were used for the synthesis of novel trifluoromethyl-containing ornithine analogues and thalidomide mimetics. Georg Thieme Verlag Stuttgart.
Tolmachova, Nataliya A.,Dolovanyuk, Violetta G.,Gerus, Igor I.,Kondratov, Ivan S.,Polovinko, Vitaliy V.,Bergander, Klaus,Haufe, Guenter
experimental part
p. 1149 - 1156
(2011/06/20)
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