The present invention provides a process for the substitution of an acylamino β-lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the β-lactam compound with an halogenating agent and a nucleophilic reagent; characterized in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a β-lactam of partial structure (I): STR1 where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.
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(2008/06/13)
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