Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors
The present invention provides pyrrolo pyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
-
Page/Page column 19
(2009/01/24)
Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors
The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC50 = 2.5 nM) and the cellular assay (ICsub
Tang, Jun,Hamajima, Toshihiro,Nakano, Masato,Sato, Hideyuki,Dickerson, Scott H.,Lackey, Karen E.
scheme or table
p. 4610 - 4614
(2009/04/08)
INHIBITORS OF Akt ACTIVITY
Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
-
Page/Page column 96-97
(2010/11/27)
More Articles about upstream products of 945865-21-4