- Method for preparing antifungal drug isavuconazonium sulfate
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The invention discloses a method for preparing isavuconazonium sulfate, and the method comprises the following steps: carrying out ion exchange on a compound shown as a formula 6 and styrene hydrogensulfate anion exchange resin in an organic solvent aqueo
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Paragraph 0057-0085
(2021/01/30)
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- Preparation method of liconazole sulfate and intermediate thereof (by machine translation)
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The preparation method disclosed by the invention has, the advantages that the preparation process efficiency of the idazooconazole sulfate and the. intermediate thereof is higher by no need C2 for column A4 chromatography and purification . and the method disclosed by, the invention only needs. to be subjected to deprotecting A4 and ion exchange by simple purification. (by machine translation)
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Paragraph 0129; 0133-0134
(2019/12/25)
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- Method for preparing isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology
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The invention discloses a method for preparing isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology, the method comprises the following steps: preparing Boc-protected isavuconazonium iodized salt from formula 1 compound isavuconazole
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Paragraph 0014; 0034-0035
(2019/10/01)
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- Isavuconazole sulfate crystal and preparation method thereof
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The invention relates to an isavuconazole sulfate crystal form, and a preparation method and a medicinal composition thereof. The crystal form has the advantages of good stability, high purity, good reappearance and suitableness for preparing medicinal preparations. The preparation method comprises the following steps: dissociating isavuconazole hydrochloride by using an alkali, carrying out salt exchange by using concentrated sulfuric acid and hydrogen peroxide, and carrying out re-crystallization. The method has the advantages of mild reaction conditions, simple post-treatment and high purity of the above product, and meets basic requirements of industrial amplified production.
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Paragraph 0037-0047
(2017/05/10)
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- A PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM OR ITS SALT THEREOF
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The present invention relates to a process for the preparation of stable Isavuconazonium or its salt thereof. In particular of the present invention relates to process for the preparing of isavuconazonium sulfate, Isavuconazonium iodide hydrochloride and
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Page/Page column 15
(2016/03/04)
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