- MEK INHIBITORS AND THERAPEUTIC USES THEREOF
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The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof. The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.
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Paragraph 0377; 0378
(2021/07/17)
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- SMALL MOLECULE INHIBITORS OF COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) AND USES THEREOF
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Compounds of formula (I), which are useful as CSF-1R inhibitors, are provided. Also provided are pharmaceutical compositions and kits comprising said compounds, as well as methods and uses pertaining to said compounds.
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Page/Page column 159; 160
(2018/07/29)
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- p27 PROTEIN INDUCER
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The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.
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Paragraph 3344-3348
(2016/10/08)
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- Optimizing the physicochemical properties of Raf/MEK inhibitors by nitrogen scanning
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Substituting a carbon atom with a nitrogen atom (nitrogen substitution) on an aromatic ring in our leads 11a and 13g by applying nitrogen scanning afforded a set of compounds that improved not only the solubility but also the metabolic stability. The impa
- Aoki, Toshihiro,Hyohdoh, Ikumi,Furuichi, Noriyuki,Ozawa, Sawako,Watanabe, Fumio,Matsushita, Masayuki,Sakaitani, Masahiro,Morikami, Kenji,Takanashi, Kenji,Harada, Naoki,Tomii, Yasushi,Shiraki, Koji,Furumoto, Kentaro,Tabo, Mitsuyasu,Yoshinari, Kiyoshi,Ori, Kazutomo,Aoki, Yuko,Shimma, Nobuo,Iikura, Hitoshi
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supporting information
p. 309 - 314
(2014/05/06)
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- INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)
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The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Page/Page column 242-243
(2012/07/27)
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- p27 PROTEIN INDUCER
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The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from -N= etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from -CH2- etc., and R2 is selected from C1-6 alkyl etc.
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