- SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins
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Fatty acid binding proteins (FABPs) serve as critical modulators of endocannabinoid signaling by facilitating the intracellular transport of anandamide and whose inhibition potentiates anandamide signaling. Our previous work has identified a novel small-m
- Yan, Su,Elmes, Matthew W.,Tong, Simon,Hu, Kongzhen,Awwa, Monaf,Teng, Gary Y.H.,Jing, Yunrong,Freitag, Matthew,Gan, Qianwen,Clement, Timothy,Wei, Longfei,Sweeney, Joseph M.,Joseph, Olivia M.,Che, Joyce,Carbonetti, Gregory S.,Wang, Liqun,Bogdan, Diane M.,Falcone, Jerome,Smietalo, Norbert,Zhou, Yuchen,Ralph, Brian,Hsu, Hao-Chi,Li, Huilin,Rizzo, Robert C.,Deutsch, Dale G.,Kaczocha, Martin,Ojima, Iwao
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p. 233 - 252
(2018/05/28)
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- α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure : Formula (I)
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Page/Page column 55
(2017/09/27)
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- The photodimerisation of the chloro-, methoxy- and nitro-derivatives of trans-cinnamic acid: A study of single crystals by vibrational microspectroscopy
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The techniques of infrared and Raman microscopy have been used to monitor the photochemical dimerisation reactions of β-2-chloro-trans-cinnamic acid, β-3-chloro-trans-cinnamic acid, β-4-chloro-trans-cinnamic acid, α-2-methoxy-trans-cinnamic acid, β-2-nitro-trans-cinnamic acid, β-3-nitro-trans-cinnamic acid and β-4-nitro-trans-cinnamic acid. In this way the topotactic nature of the reactions has been confirmed. These reactive derivatives have been compared with the unreactive γ-forms of these and related compounds.
- Atkinson, Samantha D. M.,Almond, Matthew J.,Bowmaker, Graham A.,Drew, Michael G. B.,Feltham, Emma J.,Hollins, Peter,Jenkins, Samantha L.,Wiltshire, Karen S.
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p. 1533 - 1537
(2007/10/03)
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- Radiation-induced reactions via the lowest excited states in cinnamic acid crystals
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Radiation-induced reactions of cinnamic acid derivatives have been examined and compared with photoreactions in the crystalline state; all the reaction products were exactly the same as those of the photoreactions, indicating that the reactions proceed only via the lowest excited state to give [2 + 2] cycloadducts, E/Z isomerization products, or starting molecules.
- Maekawa, Yasunari,Inaba, Tomonori,Hobo, Hiroki,Narita, Tadashi,Koshikawa, Hiroshi,Moon, Seongyun,Kato, Jun,Yoshida, Masaru
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p. 2088 - 2089
(2007/10/03)
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- Solid-State Photoreactivity of Ethyl (E)-α-Cyano-2-methoxycinnamate
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The reinvestigation of the solid-state photoreactivity of ethyl (E)-α-cyano-2-methoxycinnamate (1) allowed us to obtain the corresponding dimer which was shown to be diethyl (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylate (
- Chimichi, Stefano,Sarti-Fantoni, Piero,Coppini, Giacomo,Perghem, Franca,Renzi, Giovanni
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p. 5124 - 5126
(2007/10/02)
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