Facile synthesis of 2,3,5,6-tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1- one, a mild nitration reagent
Nitrocylcohexadienones have been applied as nitration reagents for mild, mono-nitrating reactions. The original synthesis of 2,3,5,6-tetrabromo-4-methyl- 4-nitrocylcohexa-2,5-dien-1-one appeared to be difficult to pursue due to both the solvent system and
Arnatt, Christopher K.,Zhang, Yan
experimental part
p. 1592 - 1594
(2012/04/10)
Heterocyclic cytotoxic agents
The invention provides compounds of formula I: wherein R1-R8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
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(2008/06/13)
Nitrocyclohexadienones : a new class of nitrating agents
Various nitrocyclohexadienones are proposed as new nitrating agents. These compounds are easy to prepare from corresponding phenols, easy to handle and stable. Nitrocyclohexadienones act as nitronium carriers using rearomatization as the driving force and permit nitration of highly activated substrates under mild conditions and with good yields.
13C Nuclear Magnetic Resonance Spectra of Some Bromo- and Methyl-substitued Cyclohexa-2,5-dienones
The 13C n.m.r. spectra of cyclohexa-2,5-dienones produced by bromination or nitration of a variety of methyl-substitued phenols are reported.Most of the signals have been assigned with the assistance of selective decoupling.Correlations of chemical shifts
Brittain, Judith M.,Calvert, David J.,Mare, Peter B.D. de la,Rozsas, Judith J.
p. 2005 - 2012
(2007/10/02)
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