INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER
The invention relates to compounds of formula (I): wherein R1; R2, R3, R4, R5 and are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD interaction and thu
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Paragraph 0206
(2020/04/21)
Oxidation of 1,2-Thiazoles: A Convenient Approach to 1,2-Thiazol-3(2H)-one 1,1-Dioxides
The 1,2-thiazoles obtained from 3-chloroalk-2-enals and ammonium thiocyanate (7-9, Scheme 1) are easily transformed to 1,2-thiazol-3(2H)-one 1,1-dioxides 10 on treatment with H2O2 in AcOH at 80 deg C.Hydrogenation of 10 in AcOH yields the corresponding sa