- Preparation method of tadalafil
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The invention discloses a preparation method of tadalafil. According to the method, a compound I is adopted as a starting material, the tadalafil is obtained through condensation, Fisher indole synthesis reaction, Pictet-Spengler reaction, acylation and ring closing in sequence, and dangerous reagents (n-butyllithium and the like) are not used during ring closing. The reaction route is simple, the reaction condition is mild, the purity is high, the cost is relatively low, the operation is simple and convenient, and industrial production is easy.
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- PROCESS FOR THE PREPARATION OF TADALAFIL
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The present invention provides novel intermediates of tadalafil and processes for their preparation. The present invention also provides for the preparation of tadalafil or a pharmaceutically acceptable salt or solvate thereof using the intermediates.
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Page/Page column 16-17
(2008/06/13)
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