Novel FLT3 kinase inhibitor and application thereof
The invention provides a novel FLT3 kinase inhibitor. The novel FLT3 kinase inhibitor comprises a compound shown in the formula (I) or pharmacy acceptable salt or solvate or isomer or ester or acid or metabolin or prodrug. The invention also provides a pharmaceutical composition of the compound shown in the formula (I) and an application and method of the pharmaceutical composition for preventing or treating cell proliferation disease and/or FLT3 and c-Kit related disease and disease responding to FLT3 kinase ( particularly, responding to FLT3/ITD mutant kinase) inhibition.
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Paragraph 0577; 0580
(2017/08/19)
QUINAZOLINES FOR PDK1 INHIBITION
The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
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(2008/06/13)
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