Intermodular decarboxylative direct C-3 arylation of indoles with benzoic acids
"Chemical Equation Presented" A palladium catalyzed C-H activation of indoles and a silver catalyzed decarboxylative C-C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively In the C-3 posit
Cornelia, Josep,Lu, Pengfel,Larrosa, Igor
supporting information; experimental part
p. 5506 - 5509
(2010/02/28)
Elements of regiocontrol in palladium-catalyzed oxidative arene cross-coupling
By changing the stoichiometric oxidant and modifying the indole N-substituent in palladium-catalyzed oxidative arene cross-coupling reactions, both C2 and C3 oxidative indole arylation can be achieved in high yield. High regioselectivity can also be achieved with the benzene component, and the use of this methodology with pyrrole substrates is illustrated. A mechanistic hypothesis for the change in C2/C3 selectivity is advanced. Copyright
Stuart, David R.,Villemure, Elisia,Fagnou, Keith
p. 12072 - 12073
(2008/03/27)
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