- PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS
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Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
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Page/Page column 94; 95
(2020/10/21)
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- 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
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To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discov
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Paragraph 0180
(2017/04/23)
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- NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS
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The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd
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Page/Page column 99
(2013/09/12)
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- 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS
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This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes
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Page/Page column 70
(2012/09/22)
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- 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS
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This invention relates to novel 3-aminopyridines of the formula (I) wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
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Page/Page column 150
(2012/09/21)
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- HETEROCYCLIC DERIVATIVE AND USE THEREOF
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The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like. An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.
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Page/Page column 168
(2011/01/11)
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- TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
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The present invention relates to certain (1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.
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Page/Page column 105
(2009/07/18)
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- Cell-based optimization of novel benzamides as potential antimalarial leads
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Screening our in-house compound collection using a cell based Plasmodium falciparum proliferation assay we discovered a known pan-kinase inhibitor scaffold as a hit. Further optimization of this series led us to a novel benzamide scaffold which was devoid
- Wu, Tao,Nagle, Advait,Sakata, Tomoyo,Henson, Kerstin,Borboa, Rachel,Chen, Zhong,Kuhen, Kelli,Plouffe, David,Winzeler, Elizabeth,Adrian, Francisco,Tuntland, Tove,Chang, Jonathan,Simerson, Susan,Howard, Steven,Ek, Jared,Isbell, John,Deng, Xianming,Gray, Nathanael S.,Tully, David C.,Chatterjee, Arnab K.
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scheme or table
p. 6970 - 6974
(2010/07/03)
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- Novel process and intermediates 085
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The present invention relates to a novel process suitable for large-scale production of phenyl propane derivatives as well as to novel intermediates in the process.
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Page/Page column 9-10
(2010/11/29)
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- Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
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Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table. R1R2R4Rs
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Page/Page column 18
(2010/10/20)
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