Potent antimalarial 4-pyridones with improved physico-chemical properties
Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous medi
Bueno, José M.,Manzano, Pilar,García, María C.,Chicharro, Jesús,Puente, Margarita,Lorenzo, Milagros,García, Adolfo,Ferrer, Santiago,Gómez, Rubén M.,Fraile, María T.,Lavandera, José L.,Fiandor, José M.,Vidal, Jaume,Herreros, Esperanza,Gargallo-Viola, Domingo
p. 5214 - 5218
(2011/10/02)
Novel heterocyclic compounds
4-pyridone derivatives of Formula I and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.
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(2008/06/13)
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